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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Huh-7</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><p>Bei <b>Huh-7</b> (auch <b>Huh7</b>) handelt es sich um eine <a href="Zelllinie" title="Zelllinie">Zelllinie</a>, die aus <a href="Malignit%C3%A4t" title="Malignität">bösartigen</a> <a href="Hepatozyt" title="Hepatozyt">Leberzellen</a> (malignen Hepatozyten) gewonnen wurde.
Gemäß der Website huh7.com handelt es sich um „eine gut differenzierte, von Hepatozyten abgeleitete Karzinomzelllinie, die 1982 einem Lebertumor eines 57-jährigen japanischen männlichen Patienten entnommen wurde“.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Es wird häufig in der <a href="Hepatitis-C-Virus" title="Hepatitis-C-Virus">Hepatitis-C</a>- und <a href="Denguevirus" class="mw-redirect" title="Denguevirus">Dengue</a>-Virus-Forschung eingesetzt.<sup id="cite_ref-Sainz2009_2-0" class="reference"><a href="#cite_note-Sainz2009-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup>
</p><p>Huh7-Zellen wurden maßgeblich in der Hepatitis-C-Forschung benutzt. Bis 2005 war es nämlich nicht möglich, Hepatitis-C-Viren im Labor zu kultivieren. Die Einführung der Huh7-Zelllinie ermöglichte das <a href="Screening" title="Screening">Screening</a> von <a href="Wirkstoff" title="Wirkstoff">Wirkstoffkandidaten</a> gegen das im Labor kultivierte <i>Hepatitis-C-Virus</i> und die Entwicklung neuer Wirkstoffe gegen Hepatitis C.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Sainz2009_2-1" class="reference"><a href="#cite_note-Sainz2009-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>
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<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text"><span class="cite"><a rel="nofollow" class="external text" href="https://huh7.com/"><i>Huh-7 Cell Line Origins and Characteristics.</i></a><span class="Abrufdatum"> Abgerufen am 29. März 2020</span>.</span><span style="display: none;" class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2Fde.wikipedia.org%3AHuh-7&rft.title=Huh-7+Cell+Line+Origins+and+Characteristics&rft.description=Huh-7+Cell+Line+Origins+and+Characteristics&rft.identifier=&rft.date="> </span></span>
</li>
<li id="cite_note-Sainz2009-2"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-Sainz2009_2-0">a</a></sup> <sup><a href="#cite_ref-Sainz2009_2-1">b</a></sup></span> <span class="reference-text">Bruno Sainz, Veronica Tencate, Susan L Uprichard: <cite style="font-style:italic">Three-dimensional <i>Huh7</i> cell culture system for the study of Hepatitis C virus infection</cite>. In: <cite style="font-style:italic">Virology Journal</cite>. 6. Jahrgang, 2009, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>103</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1186/1743-422X-6-103">10.1186/1743-422X-6-103</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/19604376?dopt=Abstract">PMID 19604376</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719612/">PMC 2719612</a> (freier Volltext).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rfr_id=info:sid/de.wikipedia.org:Huh-7&rft.atitle=Three-dimensional+Huh7+cell+culture+system+for+the+study+of+Hepatitis+C+virus+infection&rft.au=Bruno%26%2332%3BSainz%2C%26%2332%3BVeronica%26%2332%3BTencate%2C%26%2332%3BSusan+L%26%2332%3BUprichard&rft.btitle=Virology+Journal&rft.date=2009&rft.doi=10.1186%2F1743-422X-6-103&rft.genre=book&rft.pages=103&rft.pmc=2719612&rft.pmid=19604376&rft.volume=6.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text">Mira A. M. Behnam, Christoph Nitsche, Veaceslav Boldescu, Christian D. Klein: <cite style="font-style:italic">The medicinal chemistry of dengue virus</cite>. In: <cite style="font-style:italic">Journal of Medicinal Chemistry</cite>. 59. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>12</span>, 2016, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>5622</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1021/acs.jmedchem.5b01653">10.1021/acs.jmedchem.5b01653</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/26771861?dopt=Abstract">PMID 26771861</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Huh-7&rft.atitle=The+medicinal+chemistry+of+dengue+virus&rft.au=Mira+A.+M.%26%2332%3BBehnam%2C%26%2332%3BChristoph%26%2332%3BNitsche%2C%26%2332%3BVeaceslav%26%2332%3BBoldescu%2C+...&rft.date=2016&rft.doi=10.1021%2Facs.jmedchem.5b01653&rft.genre=journal&rft.issue=12&rft.jtitle=Journal+of+Medicinal+Chemistry&rft.pages=5622&rft.pmid=26771861&rft.volume=59.+Jahrgang" style="display:none"> </span></span>
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<li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text">R Bartenschlager, T Pietschmann: <cite style="font-style:italic">Efficient hepatitis C virus cell culture system: what a difference the host cell makes</cite>. In: <cite style="font-style:italic">Proceedings of the National Academy of Sciences of the United States of America</cite>. 102. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>28</span>, 2005, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>9739–9740</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1073/pnas.0504296102">10.1073/pnas.0504296102</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/15998731?dopt=Abstract">PMID 15998731</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175013/">PMC 1175013</a> (freier Volltext).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Huh-7&rft.atitle=Efficient+hepatitis+C+virus+cell+culture+system%3A+what+a+difference+the+host+cell+makes&rft.au=R%26%2332%3BBartenschlager%2C%26%2332%3BT%26%2332%3BPietschmann&rft.date=2005&rft.doi=10.1073%2Fpnas.0504296102&rft.genre=journal&rft.issue=28&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.pages=9739-9740&rft.pmc=1175013&rft.pmid=15998731&rft.volume=102.+Jahrgang" style="display:none"> </span></span>
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<li id="cite_note-5"><span class="mw-cite-backlink"><a href="#cite_ref-5">↑</a></span> <span class="reference-text">Volker Meier, Giuliano Ramadori: <cite style="font-style:italic">Hepatitis C virus virology and new treatment targets</cite>. In: <cite style="font-style:italic">Expert Review of Anti-infective Therapy</cite>. 7. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>3</span>, 2009, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>329–350</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1586/eri.09.12">10.1586/eri.09.12</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/19344246?dopt=Abstract">PMID 19344246</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Huh-7&rft.atitle=Hepatitis+C+virus+virology+and+new+treatment+targets&rft.au=Volker%26%2332%3BMeier%2C%26%2332%3BGiuliano%26%2332%3BRamadori&rft.date=2009&rft.doi=10.1586%2Feri.09.12&rft.genre=journal&rft.issue=3&rft.jtitle=Expert+Review+of+Anti-infective+Therapy&rft.pages=329-350&rft.pmid=19344246&rft.volume=7.+Jahrgang" style="display:none"> </span></span>
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<div class="mw-heading mw-heading2"><h2 id="Weblinks">Weblinks</h2></div>
<ul><li><a rel="nofollow" class="external text" href="https://www.cellosaurus.org/CVCL_0336">Eintrag in Cellosaurus</a></li></ul>
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